NIDDK Central Repositories Non-renewable Sample Access (X01) | PAR 17 270

Opportunity Information: Apply for PAR 17 270

The NIDDK Central Repositories Non-renewable Sample Access (X01) opportunity (PAR-17-270) is a National Institutes of Health discretionary grant mechanism designed to help researchers gain access to scarce, non-renewable biospecimens and associated data stored in the NIDDK Central Repositories. These repositories contain samples and study data collected from numerous large, well-known clinical studies funded or supported by NIDDK, meaning the materials are often uniquely valuable because they come from carefully characterized participants, standardized protocols, and long-term follow-up. The central idea of the FOA is to make it possible for investigators to conduct new scientific analyses using existing, limited samples that cannot be replaced once used, rather than initiating entirely new and expensive sample collection efforts.

A key requirement is that applicants must first verify that the specific non-renewable samples they want are actually available. The application must include documentation from the NIDDK Central Repositories confirming sample availability, which effectively means the proposal cannot be speculative; it needs to be grounded in what the repository can supply at the time of application. Detailed information on what studies are represented, what specimen types exist (for example, blood-derived components, urine, DNA, or other stored materials depending on the parent study), and what accompanying clinical or phenotypic data are available is provided through the repository website at www.niddkrepository.org. Because the samples are non-renewable, reviewers and the repository will generally expect a strong justification for sample use, an efficient study design, and analyses that make responsible use of a limited resource.

This FOA falls under the broad NIH activity areas of health and food and nutrition and is listed under CFDA 93.847. While the notice is framed as an access mechanism rather than a traditional large research project award, it still operates as a grant instrument and is intended to enable high-value research that leverages existing NIDDK-funded clinical study resources. The original closing date shown in the source information is July 30, 2019, and the opportunity was created on May 3, 2017. No award ceiling or expected number of awards is specified in the provided source text, which is common for certain NIH access or resource-oriented mechanisms where the scope and cost can vary depending on the samples and services involved.

Eligibility is broad and includes many types of U.S. governmental entities and academic institutions, along with nonprofit and for-profit organizations (including small businesses). Specifically listed eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with and without 501(c)(3) status (excluding institutions of higher education); and for-profit organizations other than small businesses, as well as small businesses. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, tribal governments that are not federally recognized, and non-U.S. (foreign) entities. In practice, this broad eligibility is meant to encourage wide scientific participation and maximize the research value that can be derived from these limited, high-quality specimens.

Overall, this opportunity is best understood as a structured pathway to request and justify access to precious, finite biospecimens linked to major NIDDK clinical studies. Investigators who can clearly demonstrate feasibility (through confirmed availability), propose a scientifically strong use of the samples, and show that their approach will generate meaningful insights from materials that cannot be replaced are the most aligned with the purpose of the X01 non-renewable sample access program.

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "NIDDK Central Repositories Non-renewable Sample Access (X01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
• This funding opportunity was created on 2017-05-03.
• Applicants must submit their applications by 2019-07-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 17 270

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