Opportunity Information: Apply for PAS 25 073
Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional) is an NIH funding opportunity (PAS-25-073) designed to expand and strengthen HIV/AIDS research that fits squarely within the scientific mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The main idea is to encourage investigators to pursue HIV-related questions where NIDDK has clear relevance, such as how HIV infection, HIV-associated inflammation, or antiretroviral therapy intersect with diabetes and other endocrine disorders, digestive and liver diseases, obesity and nutrition, and kidney and urologic conditions. Applications are expected to align with the NIH Office of AIDS Research (OAR) HIV/AIDS research priorities and the NIH guidelines used to determine whether work qualifies as HIV/AIDS research, as outlined in NOT-OD-20-018 (Update: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding). In practice, that means proposals should not only involve HIV, but should also map to recognized NIH HIV/AIDS priority areas while clearly advancing NIDDK-relevant science.
This opportunity uses the R01 mechanism, which is NIH's standard, investigator-initiated research project grant intended for substantial, multi-year research programs. The "Clinical Trial Optional" designation means you can propose either a study that does not involve a clinical trial or one that does, as long as it meets NIH definitions and is appropriate for the aims. That flexibility is helpful for projects that range from mechanistic studies in humans to intervention or implementation studies, provided the work is justified, feasible, and properly designed. The funding instrument is a grant, and the activity category is listed under Food and Nutrition and Health (CFDA 93.847), signaling the broader public health and biomedical scope while still being anchored in NIDDK's mission areas.
Eligibility is broad and includes many types of U.S. organizations and governmental entities. Standard NIH-eligible applicants listed here include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations that are not federally recognized tribal governments; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education in those nonprofit categories); for-profit organizations (other than small businesses); and small businesses. The notice also explicitly highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations. It further includes eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations), which is notable for applicants with international research components or collaborations where the science and public health justification is strong.
Administratively, the sponsoring agency is the National Institutes of Health, with NIDDK as the institute focus for mission alignment. The opportunity is categorized as discretionary funding, and the posted original closing date runs through January 7, 2028, indicating an extended window typical of NIH parent-like or priority-topic R01 announcements with multiple receipt dates over several years. The listing does not specify an award ceiling or expected number of awards in the provided source data, which usually means applicants should rely on standard NIH R01 budgeting norms, institute-specific budget guidance, and the scope of work to propose an appropriate budget. Overall, the NOFO is best understood as an open invitation for well-justified, hypothesis-driven HIV/AIDS research proposals that also meaningfully advance knowledge in diabetes, digestive disease, nutrition/obesity, or kidney/urologic health, while staying consistent with NIH-wide HIV/AIDS research priority frameworks set by OAR.Apply for PAS 25 073
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2025-01-08.
- Applicants must submit their applications by 2028-01-07.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional) (PAS-25-073)
What is this funding opportunity?
This is an NIH funding opportunity announcement (PAS-25-073) titled "Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)." It is designed to expand and strengthen HIV/AIDS research that clearly fits within the scientific mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Which NIH institute is the focus for mission alignment?
The sponsoring agency is the National Institutes of Health (NIH), and the institute focus for mission alignment is the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What type of grant mechanism is used?
This opportunity uses the R01 mechanism, NIH's standard investigator-initiated research project grant intended to support substantial, multi-year research programs.
Is a clinical trial required?
No. The opportunity is labeled "Clinical Trial Optional," meaning applicants may propose a project that does not involve a clinical trial or one that does, as long as it meets NIH definitions and is appropriate for the proposed aims.
What is the overall research focus?
The focus is HIV/AIDS research that also advances NIDDK-relevant science. Proposed projects should connect HIV infection, HIV-associated inflammation, or antiretroviral therapy to conditions within NIDDK's mission areas.
What NIDDK mission areas are specifically highlighted?
The information provided highlights intersections of HIV with diabetes and other endocrine disorders; digestive and liver diseases; obesity and nutrition; and kidney and urologic conditions.
Do projects need to address HIV/AIDS priorities beyond NIDDK's mission?
Yes. Applications are expected to align with NIH Office of AIDS Research (OAR) HIV/AIDS research priorities and the NIH guidelines used to determine whether work qualifies as HIV/AIDS research.
Which NIH guidance is referenced for determining whether a project qualifies as HIV/AIDS research?
The opportunity references NOT-OD-20-018, "Update: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding."
What does "align with OAR HIV/AIDS research priorities" mean in practice based on the description?
Based on the description provided, it means the proposal should not only involve HIV, but also map to recognized NIH HIV/AIDS priority areas while clearly advancing science relevant to NIDDK mission topics.
What kinds of study designs might fit under "Clinical Trial Optional" as described?
The description notes a range that can include mechanistic studies in humans as well as intervention or implementation studies, provided the work is justified, feasible, and properly designed.
What is the funding instrument and funding category?
The funding instrument is a grant. The opportunity is categorized as discretionary funding.
What activity category or CFDA listing is associated with this opportunity?
The activity category is listed under Food and Nutrition and Health (CFDA 93.847), reflecting broad public health and biomedical scope while remaining anchored in NIDDK mission areas.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations and governmental entities, as well as non-U.S. entities (foreign organizations) as noted in the provided information.
Which U.S. government entities are listed as eligible?
Eligible governmental applicants include state, county, and city or township governments; special district governments; and federally recognized Native American tribal governments.
Are U.S. territories or possessions eligible?
Yes. The eligibility list includes U.S. territories or possessions.
Are federal agencies eligible to apply?
Yes. The provided information states that eligible applicants include federal agencies.
Are colleges and universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are minority-serving institutions explicitly encouraged or included as eligible?
Yes. The notice explicitly highlights additional eligible applicant types including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs).
Are nonprofit organizations eligible?
Yes. Eligible applicants include nonprofits with or without 501(c)(3) status, with the caveat stated in the listing that these nonprofit categories are "as long as they are not institutions of higher education" in those nonprofit categories.
Are for-profit organizations eligible?
Yes. The listing includes for-profit organizations (other than small businesses) and also includes small businesses as eligible.
Are faith-based or community-based organizations eligible?
Yes. The eligibility description includes faith-based or community-based organizations.
Are public housing authorities eligible?
Yes. The eligibility list includes public housing authorities and Indian housing authorities.
Are non-U.S. (foreign) organizations eligible?
Yes. The provided information notes that non-U.S. entities (foreign organizations) are included, which may be relevant for international research components or collaborations where the scientific and public health justification is strong.
Does the opportunity specify an award ceiling or the expected number of awards?
No. The provided source data does not specify an award ceiling or the expected number of awards. The description suggests applicants typically rely on standard NIH R01 budgeting norms, institute-specific budget guidance, and the scope of work to propose an appropriate budget.
What is the application window or closing date mentioned?
The listing indicates an original closing date that runs through January 7, 2028, suggesting an extended window with multiple receipt dates over several years.
What kind of proposals are most appropriate for this opportunity based on the description?
The opportunity is described as an open invitation for well-justified, hypothesis-driven HIV/AIDS research proposals that meaningfully advance knowledge in diabetes, digestive disease, nutrition/obesity, or kidney/urologic health, while staying consistent with NIH-wide HIV/AIDS research priority frameworks set by OAR.
Does a project need to include antiretroviral therapy (ART) to be relevant?
Not necessarily. The description provides examples of relevant intersections, including HIV infection, HIV-associated inflammation, or antiretroviral therapy. The common requirement described is that the work involves HIV and clearly advances NIDDK-relevant science while aligning with OAR priorities and NIH HIV/AIDS qualification guidelines.
What is the main purpose of this initiative as summarized in the listing?
The main purpose is to encourage investigators to pursue HIV-related questions where NIDDK has clear relevance, strengthening HIV/AIDS research that is squarely within NIDDK mission areas and consistent with NIH-wide HIV/AIDS priority and classification frameworks.
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| NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional) Apply for PAR 25 090 Funding Number: PAR 25 090 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $225,000 |
| Collaborative Research Using Biosamples and/or Data from Type 1 Diabetes Clinical Studies (R01 - Clinical Trial Not Allowed) Apply for RFA DK 26 007 Funding Number: RFA DK 26 007 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
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| Advancing Research on the Application of Digital Health Technology to the Management of Type 2 Diabetes (R01- Clinical Trail Required) Apply for RFA DK 26 315 Funding Number: RFA DK 26 315 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
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